Methanol → Methyl cis(+/-)-5-(4-amino-3-methoxypiperidin-1-yl)-2-methoxybenzoate

HRID 43966ノート

反応式

HRID 43966 の反応式
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[CH:20][C:21]([O:28][CH3:29])=[C:22]([CH:27]=2)[C:23]([O:25][CH3:26])=[O:24])[CH2:14][C@H:13]1[O:30][CH3:31])=O)C1C=CC=CC=1.CO>[C].[Pd].C(OCC)(=O)C>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[CH:20][C:21]([O:28][CH3:29])=[C:22]([CH:27]=2)[C:23]([O:25][CH3:26])=[O:24])[CH2:14][C@H:13]1[O:30][CH3:31]

参加物

5

反応物 2

HCID 887MethanolHCID 86648847Methyl cis(+/-)-5-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-2-methoxybenzoate

生成物 1

HCID 86648848Methyl cis(+/-)-5-(4-amino-3-methoxypiperidin-1-yl)-2-methoxybenzoate

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8857Ethyl Acetate溶媒

実験手順

The same operation as in Example (40e) was performed using methyl cis(±)-5-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-2-methoxybenzoate obtained in Example (258a) (35 mg, 0.08 mmol), a 10% palladium-carbon catalyst (9 mg), methanol (1.5 mL) and ethyl acetate (1.5 mL), to obtain the title compound. The resulting compound was used for the next reaction without purification.

出典と根拠

ORDレコード
ord-e5ee5cf50c4f4d93b3d9fe133cbb4f87
出典データセット
uspto-grants-2013_09
特許番号
US08536197B2

反応ノート

読み込み中…