ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Water → Ethyl 5,5-diphenyl-2-isoxazoline-3-carboxylate

HRID 439736
ノート
印刷プレビュー

反応式

HRID 439736 の反応式
[C:1]1([C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.Cl[C:23](=[N:29][OH:30])[C:24]([O:26][CH2:27][CH3:28])=[O:25].O>CCOCC>[C:1]1([C:7]2([C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=3)[O:30][N:29]=[C:23]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 962WaterHCID 8471TriethylamineHCID 107401,1-DiphenylethyleneHCID 6816376Ethyl chloro(hydroximino)acetate

生成物 1

HCID 6451155Ethyl 5,5-diphenyl-2-isoxazoline-3-carboxylate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

13.52 g (0.075 mol) of 1,1-diphenylethene and 5.06 g (0.05 mol) of triethylamine are dissolved in 200 ml of ether at 0° C., and 7.58 g (0.05 mol) of ethyl 2-chloro-2-hydroximinoacetate, dissolved in 100 ml of ether, are subsequently added dropwise in the course of approximately two hours. After stirring has been continued for one hour at room temperature, 100 ml of H2O are added, and the mixture is subsequently extracted using ether. After drying over a MgSO4, the ether is distilled off and the residue is purified over a silica gel column (eluent: n-heptane:ethyl acetate=8:2). In this way, 12.7 g (86% of theory) of product of melting point 78° to 81° C. are obtained.

後処理

  1. additionare subsequently added dropwise in the course of approximately two hours
  2. extractionthe mixture is subsequently extracted
  3. dry with materialAfter drying over a MgSO4
  4. distillationthe ether is distilled off
  5. customthe residue is purified over a silica gel column (eluent: n-heptane:ethyl acetate=8:2)
  6. customIn this way, 12.7 g (86% of theory) of product of melting point 78° to 81° C. are obtained

出典と根拠

ORDレコード
ord-6e5d0458f33146dc89aa9bbcaaec6c49
出典データセット
uspto-grants-1996_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05516750

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート