関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | p-(Trifluoromethoxy)phenol | HCID 70015 | — |
| 反応物 | 1-Octanol, 8-bromo- | HCID 162607 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 8-(4-(Trifluoromethoxy)-phenoxy)-1-octanol | HCID 22407929 | — |
反応手順
A mixture of 5.0 g of 4-(trifluoromethoxy)phenol, 5.87 g of 8-bromo-1-octanol, and 7.76 g of K2CO3 in 56 ml of anhydrous dimethylformamide is stirred and heated at 80° C. for 16 hours. The reaction mixture is poured into dilute HCl solution and the mixture is extracted three times with ethyl acetate. The combined extracts are washed with brine and dried over MgSO4. After filtration and concentration, the crude product is purified by flash chromatography on silica gel, eluting with a 4:1 hexane/ethyl acetate mixture to give the title compound 8-(4-(trifluoromethoxy)-phenoxy)-1-octanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05516767 |
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| 出典データセット | uspto-grants-1996_05 |
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| ORD ID | ord-fba9e0b4c43c4132924eb337ae50aa28 |
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| 出典メモ | uspto-grants-1996_05 |
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