1-Bromopentane → 3-Bromophenol

HRID 439761

反応式

HRID 439761 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]>CN(C)C=O>[Br:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.[CH2:16]([O:8][CH2:4][CH2:5][CH2:6][CH2:7][CH3:2])[CH2:17][CH2:18][CH2:19][CH3:20]

参加物

6

反応物 3

HCID 80571-BromopentaneHCID 11430Potassium CarbonateHCID 115633-Bromophenol

生成物 2

HCID 115633-BromophenolHCID 12743Pentyl ether

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

To a solution of 5.0 gm of 3-Bromophenol in 60 mls of dimethylformamide is added 6.0 gm of potassium carbonate followed by 4.3 ml of 1-bromopentane. This mixture is heated to 60° C. for 6 hours and then cooled to room temperature and filtered. The filtrate is diluted with ether and washed with water and brine. After drying over magnesium sulfate and concentrating, the crude oil obtained is chromatographed over silica gel, and eluted with 3:2 hexane:ether to yield 3-bromo-phenol, n-pentyl ether as a clear oil.

後処理

  1. temperaturecooled to room temperature
  2. filtrationfiltered
  3. additionThe filtrate is diluted with ether
  4. washwashed with water and brine
  5. dry with materialAfter drying over magnesium sulfate
  6. concentrationconcentrating
  7. customthe crude oil obtained
  8. customis chromatographed over silica gel
  9. washeluted with 3:2 hexane

出典と根拠

ORDレコード
ord-797a315a2c754292b18ab6992c7363d2
出典データセット
uspto-grants-1996_05
特許番号
US05516767

関連ノート

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