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Piperazine → 1-(6-Methoxypyridin-2-yl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperazine | HCID 4837 | — |
| 反応物 | Chloroform | HCID 6212 | — |
| 反応物 | 2-Chloro-6-methoxypyridine | HCID 87009 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Ammonia | HCID 222 | 28% |
| 生成物 | 1-(6-Methoxypyridin-2-yl)piperazine | HCID 12200470 | 62.1% |
反応手順
In a sealed tube, 8.6 g of piperazine and 2.9 g (0.02 mole) of 2-chloro-6-methoxypyridine were reacted at 150° C. for 4 hours. After the reaction, the reaction mixture was applied to silica gel column chromatography (the eluent used was a mixture of chloroform: methanol : 28% aqueous ammonia = 40 : 9 : 1) to obtain 2.4 g of 1-(6-methoxy-2-pyridyl)piperazine as pale yellow liquid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05519016 |
| 出典データセット | uspto-grants-1996_05 |
| ORD ID | ord-ebced245ede149b797c0a7a977535614 |
| 出典メモ | uspto-grants-1996_05 |