1-(3-Nitropyridin-2-yl)piperazine → 2-(Piperazin-1-yl)pyridin-3-amine

HRID 440244

反応式

HRID 440244 の反応式
[N+:1]([C:4]1[C:5]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[N:6][CH:7]=[CH:8][CH:9]=1)([O-])=O.[H][H]>CO.[C].[Pd]>[NH2:1][C:4]1[C:5]([N:10]2[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]2)=[N:6][CH:7]=[CH:8][CH:9]=1

参加物

5

反応物 2

HCID 37788341-(3-Nitropyridin-2-yl)piperazineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 103973582-(Piperazin-1-yl)pyridin-3-amine収率 95.8%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

In 30 ml of methanol was dissolved 3.13 g (0.015 mole) of 1-(3-nitro-2-pyridyl)piperazine, and 2 g of 5% palladium carbon was added thereto. While stirring the mixture at room temperature, hydrogen gas was passed through for one hour. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to obtain 2.56 g of 1-(3-amino-2-pyridyl)piperazine as pale yellow liquid.

後処理

  1. additionwas added
  2. customwas passed through for one hour
  3. filtrationThe reaction mixture was filtered
  4. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-ddd5187149e74fe9b7a86c02188a48f5
出典データセット
uspto-grants-1996_05
特許番号
US05519016

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