1,2-Dichloroethane → 4-Chloro-6-ethylpyrimidine

HRID 440250ノート

反応式

HRID 440250 の反応式
[CH2:1]([C:3]1[N:8]=[CH:7][N:6]=[C:5](O)[CH:4]=1)[CH3:2].[Cl:10]CCCl.P(Cl)(Cl)(Cl)=O>O>[Cl:10][C:5]1[CH:4]=[C:3]([CH2:1][CH3:2])[N:8]=[CH:7][N:6]=1

参加物

5

反応物 3

HCID 111,2-DichloroethaneHCID 24813Phosphorus oxychlorideHCID 178436949HCID 178436949、化合物

生成物 1

HCID 111372714-Chloro-6-ethylpyrimidine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To 12.4 g (0.1 mole) of 6-ethyl-4-hydroxypyrimidine was added 50 ml of 1,2-dichloroethane, and 18.4 g (0.12 mole) of phosphorus oxychloride was added thereto. The mixture was refluxed by heating for 3 hours. After cooling, water was added to the reaction mixture, and the mixture was extracted with chloroform. The chloroform layer was washed with water and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to obtain 10.38 g of 4-chloro-6-ethylpyrimidine as slightly red liquid.

後処理

  1. additionwas added
  2. temperatureThe mixture was refluxed
  3. temperatureby heating for 3 hours
  4. temperatureAfter cooling
  5. extractionthe mixture was extracted with chloroform
  6. washThe chloroform layer was washed with water
  7. dry with materialdried over anhydrous sodium sulfate
  8. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-2f8a20d7c608420bb34ca0e47436f0e4
出典データセット
uspto-grants-1996_05
特許番号
US05519016

反応ノート

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