2-Bromothiazole → 1211507-79-7
反応式
[Li]CCCC.Br[C:7]1[S:8][CH:9]=[CH:10][N:11]=1.[CH:12]1([CH:15]=[O:16])[CH2:14][CH2:13]1>CCOCC>[OH:16][CH:15]([C:7]1[S:8][CH:9]=[CH:10][N:11]=1)[CH:12]1[CH2:14][CH2:13]1参加物
5
反応条件
- 温度
- -78 °C
実験手順
n-BuLi (26.7 mL, 42.8 mmol, 1.6M) was added dropwise to a -78° C. solution of 2-bromothiazole (6.7 g, 40.8 mmol) in dry Et2O (80 mL). After stirring at -78° C. for 1 h, cyclopropanal (32 mL, 42.8 mmol) was added and the solution stirred 30 min. The reaction was quenched with water, the layers separated and the aqueous extracted with EtOAc. The combined extracts were dried (MgSO4), and condensed. The crude material was purified by flash chromatography using 40% EtOAc/hexane to give 5.98 g (95%) of 2-(1-hydroxy-1-cyclopropylmethyl)thiazole as a yellow oil.
後処理
- stirringthe solution stirred 30 min
- customThe reaction was quenched with water
- customthe layers separated
- extractionthe aqueous extracted with EtOAc
- customThe combined extracts were dried
- custom(MgSO4), and condensed
- customThe crude material was purified by flash chromatography
出典と根拠
- ORDレコード
- ord-8b743ce7939d46f8aefb0adc7500f544
- 出典データセット
- uspto-grants-1996_05
- 特許番号
- US05519040
反応ノート
読み込み中…