Methanol → Methyl 2-(4-fluorophenyl)acetate

HRID 440384

反応式

HRID 440384 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.[CH3:12]O>S(=O)(=O)(O)O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 887MethanolHCID 98372-(4-Fluorophenyl)acetic acid

生成物 1

HCID 2733233Methyl 2-(4-fluorophenyl)acetate

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid触媒

反応条件

温度
50 °C

実験手順

Combine 4-fluorophenylacetic acid (10.6 g, 68.8 mmol) and anhydrous methanol (100 mL). Add concentrated sulfuric acid (3 drops). Heat at 50° C. After 12 hours, cool to ambient temperature and evaporate most of the solvent in vacuo. Dilute the evaporated reaction mixture with ether, extract with aqueous saturated sodium bicarbonate solution and brine. Dry over MgSO4 filter and allow to stand until a solid forms. Collect the solid by filtration to give methyl 4-fluorophenylacetate which may be used without further purification.

後処理

  1. temperaturecool to ambient temperature
  2. customevaporate most of the solvent in vacuo
  3. additionDilute
  4. customthe evaporated reaction mixture with ether
  5. extractionextract with aqueous saturated sodium bicarbonate solution and brine
  6. dry with materialDry over MgSO4
  7. filtrationfilter
  8. customCollect the solid
  9. filtrationby filtration

出典と根拠

ORDレコード
ord-e8e4633672dc4bd5998555ecc3cc0e41
出典データセット
uspto-grants-1996_05
特許番号
US05519048

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