Isopropanol → Tert-butyl 2-bromo-2-(diethoxyphosphoryl)acetate

HRID 440388ノート

反応式

HRID 440388 の反応式
[CH2:1]([O:3][P:4]([C:9](Br)([Br:17])[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])([O:6][CH2:7][CH3:8])=[O:5])[CH3:2].C(O)(C)C.[Sn](Cl)Cl>O>[CH2:1]([O:3][P:4]([CH:9]([Br:17])[C:10]([O:12][C:13]([CH3:14])([CH3:16])[CH3:15])=[O:11])([O:6][CH2:7][CH3:8])=[O:5])[CH3:2]

参加物

5

反応物 3

HCID 3776IsopropanolHCID 24479Stannous ChlorideHCID 21263367HCID 21263367、化合物

生成物 1

HCID 21263365Tert-butyl 2-bromo-2-(diethoxyphosphoryl)acetate

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
0 °C

実験手順

Combine t-butyl diethylphosphonodibromoacetate (75.6 g, 184 mmol) and isopropanol (190 mL). Cool to 0° C. Add a solution of tin (II) chloride (33.2 g, 175 mmol) in water (190 mL). After the addition is complete, warm to ambient temperature. After 1 hour, extract the reaction mixture three times with chloroform. Combine the organic layers and extract with water, dry over MgSO4, filter, and evaporate in vacuo to give the title compound.

後処理

  1. additionAfter the addition
  2. temperaturewarm to ambient temperature
  3. extractionextract the reaction mixture three times with chloroform
  4. extractionextract with water
  5. dry with materialdry over MgSO4
  6. filtrationfilter
  7. customevaporate in vacuo

出典と根拠

ORDレコード
ord-731871366ac4462d81e184affa73d2c1
出典データセット
uspto-grants-1996_05
特許番号
US05519048

反応ノート

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