Hydrochloric Acid → 1-(4-Methoxyphenyl)cyclobutane-1-carboxylic acid

HRID 440532ノート

反応式

HRID 440532 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:13]#N)[CH2:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[OH-:15].[K+].C(O)COCCO.Cl.[OH2:25]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:13]([OH:25])=[O:15])[CH2:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1

参加物

6

反応物 5

HCID 313Hydrochloric AcidHCID 962WaterHCID 8117Diethylene GlycolHCID 14797Potassium HydroxideHCID 219020981-(4-Methoxyphenyl)cyclobutane-1-carbonitrile

生成物 1

HCID 167699461-(4-Methoxyphenyl)cyclobutane-1-carboxylic acid

実験手順

A mixture of 1-(4-methoxyphenyl)cyclobutane carbonitrile (41 g), potassium hydroxide (20 g) and diethylene glycol (160 ml) was heated under reflux for 3.5 hours. The mixture was added to water, acidified with dilute hydrochloric acid and extracted with ether. The extract yielded 1-(4-methoxyphenyl)cyclobutane carboxylic acid.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 3.5 hours
  3. extractionextracted with ether

出典と根拠

ORDレコード
ord-b88dba37139741bea049d5b66a6142bf
出典データセット
uspto-grants-1996_05
特許番号
US05519034

反応ノート

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