Hydrochloric Acid → Aminocaproic acid hydrochloride

HRID 440618ノート

反応式

HRID 440618 の反応式
[C:1]1(=[O:8])[NH:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:9].[OH2:10]>>[ClH:9].[NH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][C:1]([OH:8])=[O:10]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 7768Caprolactam

生成物 1

HCID 12205345Aminocaproic acid hydrochloride

実験手順

ε-Caprolactam (750.00 g, 6.63 mol), water (1500 mL), and concentrated HCl (675 mL, 36-38%) are combined in a 5000 mL three-necked round bottomed flask fitted with a mechanical stirrer and condenser. The mixture is heated for 4 h at reflux, cooled to room temperature, and concentrated by rotary evaporation at 50° C. (water aspirator vacuum) to give 1 as a white solid. The absence of ε-caprolactam by TLC (Rf =0.21, THF) indicates the reaction is complete.

後処理

  1. customfitted with a mechanical stirrer and condenser
  2. temperatureThe mixture is heated for 4 h
  3. temperatureat reflux
  4. concentrationconcentrated by rotary evaporation at 50° C. (water aspirator vacuum)

出典と根拠

ORDレコード
ord-c2fc306c784b4fdc90d964b63133d26b
出典データセット
uspto-grants-1996_05
特許番号
US05520835

反応ノート

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