Boron tribromide → Phenol, 5-chloro-2-nitro-

HRID 440650

反応式

HRID 440650 の反応式
B(Br)(Br)Br.[Cl:5][C:6]1[CH:7]=[CH:8][C:9]([N+:14]([O-:16])=[O:15])=[C:10]([O:12]C)[CH:11]=1>C(Cl)Cl>[Cl:5][C:6]1[CH:7]=[CH:8][C:9]([N+:14]([O-:16])=[O:15])=[C:10]([OH:12])[CH:11]=1

参加物

4

反応物 2

HCID 25134Boron tribromideHCID 811105-Chloro-2-nitroanisole

生成物 1

HCID 11900Phenol, 5-chloro-2-nitro-収率 90.5%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A 1M solution of boron tribromide in methylene chloride (400 mL, 0.40 mole) was cooled to -20° C. A solution of 37.5 g (0.20 mole) of 5-chloro-2-nitroanisole in 200 mL of methylene chloride was added slowly to the first solution. Upon completion of addition, the mixture was allowed to warm to ambient temperature at which it stirred for about 16 hours. At the conclusion of this period the reaction mixture was poured into ice water. The organic layer was separated from the aqueous layer and was evaporated under reduced pressure, leaving 31.40 g of 5-chloro-2-nitrophenol as a solid residue, m.p. 38°-39° C.

後処理

  1. additionUpon completion of addition
  2. customThe organic layer was separated from the aqueous layer
  3. customwas evaporated under reduced pressure

出典と根拠

ORDレコード
ord-37fa2d71589d41f490cc9af9baa1e593
出典データセット
uspto-grants-1996_05
特許番号
US05521147

関連ノート

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