Methallyl alcohol → 4-Chloro-2-(2-methyl-2-propen-1-yloxy)nitrobenzene

HRID 440651

反応式

HRID 440651 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([OH:8])[CH:7]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:18][C:19](=[CH2:22])[CH2:20]O>CC(=O)CC>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([O:8][CH2:20][C:19]([CH3:22])=[CH2:18])[CH:7]=1

参加物

5

反応物 3

HCID 10557Methallyl alcoholHCID 11430Potassium CarbonateHCID 11900Phenol, 5-chloro-2-nitro-

生成物 1

HCID 224048134-Chloro-2-(2-methyl-2-propen-1-yloxy)nitrobenzene収率 84%

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

反応条件

温度
80 °C

実験手順

A mixture of 30.0 g (0.17 mole) of 5-chloro-2-nitrophenol, 30.49 g (0.221 mole) of potassium carbonate, and 18.47 g (0.204 mole) of 2-methyl-2-propen-1-ol in 200 mL of 2-butanone was heated at 80° C. for approximately 16 hours. During this period the reaction changed color from orange to pale yellow. At the conclusion of this period the reaction mixture was filtered, and the filtrate was evaporated under reduced pressure, leaving 32.50 g of 4-chloro-2-(2-methyl-2-propen-1-yloxy)nitrobenzene as a solid residue, m.p. 47°-49° C.

後処理

  1. waitDuring this period the reaction changed
  2. filtrationAt the conclusion of this period the reaction mixture was filtered
  3. customthe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-d371590700f54983b1d7d2d0dc81456b
出典データセット
uspto-grants-1996_05
特許番号
US05521147

関連ノート

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