Potassium Carbonate → 2-Amino-3-cyano-5-ethynylpyrazine

HRID 440901ノート

反応式

HRID 440901 の反応式
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[N:6][C:5]([C:10]#[C:11][Si](C)(C)C)=[CH:4][N:3]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[N:6][C:5]([C:10]#[CH:11])=[CH:4][N:3]=1

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 153352712-Amino-3-cyano-5-(trimethylsilylethynyl)pyrazine

生成物 1

HCID 153352732-Amino-3-cyano-5-ethynylpyrazine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 1.3 grams (0.006 mole) of 2-amino-3-cyano-5-(trimethylsilylethynyl)pyrazine and 0.9 gram (0.006 mole) of potassium carbonate in 50 mL of methanol is stirred at ambient temperature for one hour. The reaction mixture is then concentrated under reduced pressure to a residue. The residue is taken up in about 75 mL of water, and the solution is extracted with two 200 mL portions of ethyl acetate. The combined extracts are dried with magnesium sulfate and filtered. The filtrate is concentrated under reduced pressure, yielding 2-amino-3-cyano-5-ethynylpyrazine. This reaction is repeated several times.

後処理

  1. concentrationThe reaction mixture is then concentrated under reduced pressure to a residue
  2. extractionthe solution is extracted with two 200 mL portions of ethyl acetate
  3. dry with materialThe combined extracts are dried with magnesium sulfate
  4. filtrationfiltered
  5. concentrationThe filtrate is concentrated under reduced pressure

出典と根拠

ORDレコード
ord-2870652595d84b51bcae25d82eabd9b5
出典データセット
uspto-grants-1996_05
特許番号
US05521190

反応ノート

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