Benzyloxyamine hydrochloride → HCID 53904346、化合物

HRID 440919

反応式

HRID 440919 の反応式
[C:1]1(=O)[CH:8]2[N:4]3[CH2:5][CH:6]([CH2:9][CH:2]1[CH2:3]3)[CH2:7]2.Cl.[CH2:12]([O:19][NH2:20])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>N1C=CC=CC=1.C(O)C>[C:13]1([CH2:12][O:19][N:20]=[C:1]2[CH:8]3[N:4]4[CH2:5][CH:6]([CH2:9][CH:2]2[CH2:3]4)[CH2:7]3)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

4

反応物 2

HCID 102312Benzyloxyamine hydrochlorideHCID 18542506HCID 18542506、化合物

生成物 1

HCID 53904346HCID 53904346、化合物

試薬・触媒・溶媒 1

HCID 21975839Pyridine ethanol溶媒

実験手順

Hexahydro-2,6-methano-1H-pyrrolizin-1-one (N. Speckamp, Tetrahedron, 27, 3143 (1971)), 1.45 g, 11.0 mmol, was dissolved in a 1:1 solution of pyridine/ethanol (20 mL). O-Benzyl hydroxylamine hydrochloride (1.85 g, 11.6 mmol) was added and the solution was stirred for 20 hours at room temperature. Removal of the solvents in vacuo afforded a solid which was purified by chromatography on silica gel eluting with 10% MeOH (NH3)/CHCl3 to give hexahydro-1-[(phenylmethoxy) imino]-2,6-methano-1H-pyrrolizine.

後処理

  1. customRemoval of the solvents in vacuo
  2. customafforded a solid which
  3. customwas purified by chromatography on silica gel eluting with 10% MeOH (NH3)/CHCl3

出典と根拠

ORDレコード
ord-2d49ed135f6142cf980947c604af0ef5
出典データセット
uspto-grants-1996_05
特許番号
US05521193

関連ノート

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