N,N-Dimethyl-1,4-dioxaspiro[4.5]decan-8-amine → 4-(Dimethylamino)cyclohexan-1-one

HRID 440930ノート

反応式

HRID 440930 の反応式
C1O[C:4]2([CH2:9][CH2:8][CH:7]([N:10]([CH3:12])[CH3:11])[CH2:6][CH2:5]2)[O:3]C1>C(O)=O>[CH3:11][N:10]([CH3:12])[CH:7]1[CH2:8][CH2:9][C:4](=[O:3])[CH2:5][CH2:6]1

参加物

3

反応物 1

HCID 361167N,N-Dimethyl-1,4-dioxaspiro[4.5]decan-8-amine

生成物 1

HCID 103745454-(Dimethylamino)cyclohexan-1-one収率 100%

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

4.96 gm (26.8 mMol) 4-dimethylamino-1-cyclohexanone ethylene ketal were dissolved in 50 mL formic acid and the solution stirred at reflux for 18 hours. The reaction mixture was then cooled to ambient and the volatiles removed under reduced pressure to give 3.78 gm (100%) of the title compound.

後処理

  1. temperatureat reflux for 18 hours
  2. temperatureThe reaction mixture was then cooled to ambient and the volatiles
  3. customremoved under reduced pressure

出典と根拠

ORDレコード
ord-752333a4880d48bdaa644ff51dd114b4
出典データセット
uspto-grants-1996_05
特許番号
US05521196

反応ノート

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