Water → 12-Methanesulfonyl-1-dodecene

HRID 441135ノート

反応式

HRID 441135 の反応式
[CH2:1](O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH:11]=[CH2:12].[CH3:14][S:15](Cl)(=[O:17])=[O:16].C(N(CC)CC)C.O>ClCCl>[CH3:14][S:15]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH:11]=[CH2:12])(=[O:17])=[O:16]

参加物

6

反応物 4

HCID 962WaterHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 52072511-Dodecen-1-ol

生成物 1

HCID 2329589712-Methanesulfonyl-1-dodecene

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

To a solution of 11-dodecen-1-ol (5.5 g, 29.9 mmol) in dichloromethane (70 ml) at 0° C. was added methanesulfonyl chloride (3.55 g, 2.40 ml, 31.0 mmol) followed by triethylamine (4.38 g, 46.0 mmol). After stirring for 10 min at 0° C., the reaction was allowed to warm to 25° C. and stirred for 2 hr. The reaction was poured into water (60 ml), separated and washed with dichloromethane (50 ml). The organic portions were combined, dried (magnesium sulfate), and evaporated to give the 12-methanesulfonyl-1-dodecene as a yellow oil which was used without further purification.

後処理

  1. temperatureto warm to 25° C.
  2. stirringstirred for 2 hr
  3. customseparated
  4. washwashed with dichloromethane (50 ml)
  5. dry with materialdried (magnesium sulfate)
  6. customevaporated

出典と根拠

ORDレコード
ord-b6be420efe4346cb9ab796199f7df8f3
出典データセット
uspto-grants-1996_05
特許番号
US05521315

反応ノート

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