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Water → 4-[2-Hydroxy-2-(5-methyl-phenyl-4-oxazolyl)ethoxy]benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | 4-[2-(5-Methyl-2-phenyl-4-oxazolyl)-2-oxoethoxy]benzonitrile | HCID 13713979 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-[2-Hydroxy-2-(5-methyl-phenyl-4-oxazolyl)ethoxy]benzonitrile | HCID 54287204 | 92.7% |
反応手順
Sodium borohydride (0.654 mg) was added to a suspension of 4-[2-(5-methyl-2-phenyl-4-oxazolyl)-2-oxoethoxy]benzonitrile (5.5 g) in methanol (100 ml)-N,N-dimethylformamide (50 ml), followed by stirring at room temperature for 1 hour. The reaction solution was poured into water and the crystals which separated out were collected by filtration to give 4-[2-hydroxy-2-(5-methyl-phenyl-4-oxazolyl)ethoxy]benzonitrile (5.1 g, 92.7%). Recrystallization from acetone afforded colorless neddles, m.p. 176°-177° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04725610 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-2f9a930e708d48b38d38a3a790caddee |
| 出典メモ | uspto-grants-1988_02 |