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Phenylsulphonyl isocyanate → 2-[2-Oxo-6-phenyl-3-(3-phenylsulfonylureido)-1,2-dihydro-1-pyridyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenylsulphonyl isocyanate | HCID 76096 | — |
| 反応物 | 2-(3-Amino-2-oxo-6-phenyl-2H-pyridin-1-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-acetamide | HCID 10250073 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-[2-Oxo-6-phenyl-3-(3-phenylsulfonylureido)-1,2-dihydro-1-pyridyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide | HCID 22405567 | 96.4% |
反応手順
To 2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide (0.5 g) in dichloromethane (40 mL) was added benzenesulfonyl isocyanate (0.23 g), and the resulting solution was allowed to stir for 1 h. The solvent was evaporated and the product was purified by chromatography to provide the title compound (0.7 g); chromatography solvent: methanol:dichloromethane (5:95); TLC: Rf =0.6, methanol:dichloromethane (10:90); MS: m/z=579(M+1), 577(M-1) by FAB.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05521179 |
| 出典データセット | uspto-grants-1996_05 |
| ORD ID | ord-0b587c787bfe494e82e884f6c858bc05 |
| 出典メモ | uspto-grants-1996_05 |