2-Nitroaniline → Benzamide, 4-nitro-N-(2-nitrophenyl)-

HRID 441227ノート

反応式

HRID 441227 の反応式
[N+:1]([C:4]1[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=1[NH2:6])([O-:3])=[O:2].C(N(CC)CC)C.[N+:18]([C:21]1[CH:29]=[CH:28][C:24]([C:25](Cl)=[O:26])=[CH:23][CH:22]=1)([O-:20])=[O:19]>ClCCl>[N+:1]([C:4]1[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=1[NH:6][C:25](=[O:26])[C:24]1[CH:23]=[CH:22][C:21]([N+:18]([O-:20])=[O:19])=[CH:29][CH:28]=1)([O-:3])=[O:2]

参加物

5

反応物 3

HCID 69462-NitroanilineHCID 8471TriethylamineHCID 85024-Nitrobenzoyl chloride

生成物 1

HCID 5155676Benzamide, 4-nitro-N-(2-nitrophenyl)-収率 63.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a mixture of 2-nitroaniline (1.38 g) and triethylamine (1.67 ml) in dichloromethane (30 ml) were added 4-nitrobenzoyl chloride (1.85 g) and the solution was stirred at ambient temperature for 4 hours. The solution was washed successively with 1N hydrochloric acid, saturated aqueous sodium hydrogencarbonate, water and brine, and the organic layer was dried over magnesium sulfate. The solvent was evaporated in vacuo and the residue was solidified with n-hexane to give 2-nitro-N-(4nitrobenzoyl)aniline (1.82 g).

後処理

  1. washThe solution was washed successively with 1N hydrochloric acid, saturated aqueous sodium hydrogencarbonate, water and brine
  2. dry with materialthe organic layer was dried over magnesium sulfate
  3. customThe solvent was evaporated in vacuo

出典と根拠

ORDレコード
ord-884c8b27e2124b9c80f5c99e079dfec6
出典データセット
uspto-grants-1996_05
特許番号
US05521170

反応ノート

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