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Triethylamine → 1-{4-[2-(1-Pyrrolyl)benzoylamino]benzoyl}-1,2,3,4tetrahydroquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Diphenyl chlorophosphate | HCID 75654 | — |
| 反応物 | 2-(1H-pyrrol-1-yl)benzoic acid | HCID 728521 | — |
| 反応物 | (4-aminophenyl)(3,4-dihydroquinolin-1(2H)-yl)methanone | HCID 2984117 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-{4-[2-(1-Pyrrolyl)benzoylamino]benzoyl}-1,2,3,4tetrahydroquinoline | HCID 10598275 | 60.5% |
反応手順
To a solution of 2-(1-pyrrolyl)benzoic acid (206 mg), diphenyl chlorophosphate (325 mg), 1-(4-aminobenzoyl}-1,2,3,4-tetrahydroquinoline (277 mg) in tetrahydrofuran (10 ml) was added triethylamine (333 mg) at 0° C. The resulting mixture was allowed to warm to ambient temperature where it was maintained for 5 hours. The solvent was evaporated and diluted with ethyl acetate and washed with water, saturated sodium bicarbonate aqueous solution and brine. The organic layer was dried over sodium sulfate and concentrated to give 1-{4-[2-(1-pyrrolyl)benzoylamino]benzoyl}-1,2,3,4tetrahydroquinoline (280 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05521170 |
| 出典データセット | uspto-grants-1996_05 |
| ORD ID | ord-b85ecc7cd5d44739bc7c54ad7db59d8c |
| 出典メモ | uspto-grants-1996_05 |