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Triethylamine → 1-{4-[2-(2-Carboxyphenyl)benzoylamino]benzoyl}-1,2,3,4-tetrahydroquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Diphenic anhydride | HCID 72794 | — |
| 反応物 | (4-aminophenyl)(3,4-dihydroquinolin-1(2H)-yl)methanone | HCID 2984117 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-{4-[2-(2-Carboxyphenyl)benzoylamino]benzoyl}-1,2,3,4-tetrahydroquinoline | HCID 22405102 | 84% |
反応手順
A mixture of 1-(4-aminobenzoyl)-1,2,3,4-tetrahydroquinoline (252 mg), diphenic anhydride (224 mg), triethylamine (202 mg) and catalytic amount of 4-dimethylaminopyridine in dichloromethane (15 ml) was stirred for 8 hours at ambient temperature. The mixture was evaporated in vacuo and diluted with ethyl acetate and washed with saturated sodium hydrogen carbonate aqueous solution, brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo and triturated from ethyl acetate to give 1-{4-[2-(2-carboxyphenyl)benzoylamino]benzoyl}-1,2,3,4-tetrahydroquinoline (400 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05521170 |
| 出典データセット | uspto-grants-1996_05 |
| ORD ID | ord-0cfb53e26d7849009cbdc96b6092b079 |
| 出典メモ | uspto-grants-1996_05 |