Triethylamine → 1-{4-[2-(2-Carboxyphenyl)benzoylamino]benzoyl}-1,2,3,4-tetrahydroquinoline

HRID 441249

反応式

HRID 441249 の反応式
[NH2:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([N:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH2:11][CH2:10][CH2:9]2)=[O:7])=[CH:4][CH:3]=1.[C:20]12[C:27]3=[CH:28][CH:29]=[CH:30][CH:31]=[C:26]3[C:25](=[O:32])[O:24][C:22](=[O:23])[C:21]1=[CH:33][CH:34]=[CH:35][CH:36]=2.C(N(CC)CC)C>CN(C)C1C=CN=CC=1.ClCCl>[C:22]([C:21]1[CH:33]=[CH:34][CH:35]=[CH:36][C:20]=1[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=1[C:25]([NH:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([N:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH2:11][CH2:10][CH2:9]2)=[O:7])=[CH:4][CH:3]=1)=[O:32])([OH:24])=[O:23]

参加物

6

反応物 3

HCID 8471TriethylamineHCID 72794Diphenic anhydrideHCID 2984117(4-aminophenyl)(3,4-dihydroquinolin-1(2H)-yl)methanone

生成物 1

HCID 224051021-{4-[2-(2-Carboxyphenyl)benzoylamino]benzoyl}-1,2,3,4-tetrahydroquinoline収率 84%

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of 1-(4-aminobenzoyl)-1,2,3,4-tetrahydroquinoline (252 mg), diphenic anhydride (224 mg), triethylamine (202 mg) and catalytic amount of 4-dimethylaminopyridine in dichloromethane (15 ml) was stirred for 8 hours at ambient temperature. The mixture was evaporated in vacuo and diluted with ethyl acetate and washed with saturated sodium hydrogen carbonate aqueous solution, brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo and triturated from ethyl acetate to give 1-{4-[2-(2-carboxyphenyl)benzoylamino]benzoyl}-1,2,3,4-tetrahydroquinoline (400 mg).

後処理

  1. customThe mixture was evaporated in vacuo
  2. additiondiluted with ethyl acetate
  3. washwashed with saturated sodium hydrogen carbonate aqueous solution, brine
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent was evaporated in vacuo
  6. customtriturated from ethyl acetate

出典と根拠

ORDレコード
ord-0cfb53e26d7849009cbdc96b6092b079
出典データセット
uspto-grants-1996_05
特許番号
US05521170

関連ノート

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