Diketene → HCID 21419830、化合物

HRID 441277ノート

反応式

HRID 441277 の反応式
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.[NH2:7][C:8]1[CH:9]=[C:10]([CH:18]=[CH:19][CH:20]=1)[NH:11][C:12](=[O:17])[CH2:13][CH2:14][CH2:15][CH3:16]>C1C=CC=CC=1>[C:12]([NH:11][C:10]1[CH:9]=[C:8]([CH:20]=[CH:19][CH:18]=1)[NH:7][C:4](=[O:5])[CH2:3][C:2](=[O:6])[CH3:1])(=[O:17])[CH2:13][CH2:14][CH2:15][CH3:16]

参加物

4

反応物 2

HCID 12661DiketeneHCID 5138852N-(3-aminophenyl)pentanamide

生成物 1

HCID 21419830HCID 21419830、化合物収率 24.6%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

反応条件

温度
20 °C

実験手順

42 g of diketene were added to a mixture of 96 g of m-aminovaleranilide in 400 ml of benzene and the mixture was stirred for 16 hours at 20° C. The benzene was decanted and the residue was added to refluxing benzene. The mixture was treated with activated carbon and filtered to obtain raw m-valeramido-acetylacetanilide melting at 90° C. Crystallization from ethyl acetate yielded 34 g of pure m-valeramido-acetylacetanilide melting at 116° C.

後処理

  1. customThe benzene was decanted
  2. additionthe residue was added
  3. temperatureto refluxing benzene
  4. additionThe mixture was treated with activated carbon
  5. filtrationfiltered
  6. customto obtain raw m-valeramido-acetylacetanilide melting at 90° C
  7. customCrystallization from ethyl acetate

出典と根拠

ORDレコード
ord-8d826342c94249ddbeca380895b4516c
出典データセット
uspto-grants-1977_08
特許番号
US04039316

反応ノート

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