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Sodium Hydroxide → Drometrizole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4-Methyl-2-[2-(2-nitrophenyl)diazenyl]phenol | HCID 74029 | — |
| 反応物 | 2-Nitro-2'-hydroxy-3',5'-bis(tert-amyl)azobenzene | HCID 104111 | — |
| 反応物 | Diazene, (nitrophenyl)phenyl-, (E)- | HCID 142206 | — |
| 生成物 | Drometrizole | HCID 17113 | — |
反応手順
When in Example 1, the 2'-hydroxy-3',5'-di-tert-amyl-2-nitroazobenzene was replaced by an equivalent amount of 2'-hydroxy-5'-methyl-2-nitroazobenzene and the mole ratio of sodium hydroxide to o-nitroazobenzene intermediate was increased from 0.42/1 to 1.26/1, the reaction went rapidly to yield the product 2-(2-hydroxy-5-methylphenyl)-2H-benzotriazole.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04041044 |
| 出典データセット | uspto-grants-1977_08 |
| ORD ID | ord-51913da19f294f22b2c30d29c6a754fb |
| 出典メモ | uspto-grants-1977_08 |