Methyl 2-methyl-3-(phenylmethoxy)propanoate → 3-Benzyloxy-2-methylpropan-1-ol

HRID 441553

反応式

HRID 441553 の反応式
C[O:2][C:3](=O)[CH:4]([CH3:14])[CH2:5][O:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[H-].COCCO[Al+]OCCOC.[Na+].[H-]>>[CH2:7]([O:6][CH2:5][CH:4]([CH3:14])[CH2:3][OH:2])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参加物

3

反応物 2

HCID 13531536Methyl 2-methyl-3-(phenylmethoxy)propanoateHCID 21584525Sodium bis(2-methoxyethoxy)aluminiumhydride

生成物 1

HCID 5622083-Benzyloxy-2-methylpropan-1-ol収率 90.5%

実験手順

Reduction of the rac.-methyl-3-benzyloxy-2-methylpropionate was carried out with sodium bis(2-methoxyethoxy)-aluminum hydride using the procedure described in Example 9. Distillation of the crude product afforded the rac. 3-benzyloxy-2-methyl-1-propanol in 90.5% yield as a colorless liquid, b.p. 94°-98° C. (0.1 mm Hg.).

後処理

  1. distillationDistillation of the crude product

出典と根拠

ORDレコード
ord-1ba07ab022f7429c932a7b58e0466687
出典データセット
uspto-grants-1977_08
特許番号
US04041058

関連ノート

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