Morpholine → 4-(3-Chloropyrazin-2-YL)morpholine

HRID 441729

反応式

HRID 441729 の反応式
Cl[C:2]1[C:7]([Cl:8])=[N:6][CH:5]=[CH:4][N:3]=1.[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>CN(C)C=O>[Cl:8][C:7]1[C:2]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[N:3][CH:4]=[CH:5][N:6]=1

参加物

4

反応物 2

HCID 8083MorpholineHCID 785752,3-Dichloropyrazine

生成物 1

HCID 205289944-(3-Chloropyrazin-2-YL)morpholine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 2,3-dichloropyrazine (5 g., 0.034 mmole), morpholine (5.8 g., 0.067 mmole), and 50 ml. of dimethylformamide are heated at 90°-120° C. for 6-14 hours, in an atmosphere of nitrogen. The reaction mixture is cooled and evaporated to dryness at a water-bath temperature of 55° C. A chloroform solution of the residue is extracted twice with 0.1M sodium hydroxide, dried over magnesium sulfate and evaporated to leave the product.

後処理

  1. temperatureThe reaction mixture is cooled
  2. customevaporated to dryness at a water-bath temperature of 55° C
  3. extractionA chloroform solution of the residue is extracted twice with 0.1M sodium hydroxide
  4. dry with materialdried over magnesium sulfate
  5. customevaporated
  6. customto leave the product

出典と根拠

ORDレコード
ord-c4676298a1bb4cf5b68cda20689a6741
出典データセット
uspto-grants-1977_08
特許番号
US04042586

関連ノート

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