Benzene, 1-iodo-3-(trifluoromethyl)- → 5-methyl-1(3'-trifluoromethylphenyl)-2-(1H)-pyridone

反応式

[CH3:1][C:2]1[CH:3]=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.[F:9][C:10]([F:19])([F:18])[C:11]1[CH:12]=[C:13](I)[CH:14]=[CH:15][CH:16]=1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5](=[O:8])[N:6]([C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:10]([F:19])([F:18])[F:9])[CH:16]=2)[CH:7]=1

参加物

反応物 2

HCID 67868Benzene, 1-iodo-3-(trifluoromethyl)-

HCID 704822-Hydroxy-5-methylpyridine

生成物 1

HCID 98379115-methyl-1(3'-trifluoromethylphenyl)-2-(1H)-pyridone収率 78%

実験手順

The reaction of 5-methyl-2- (1H)-pyridone with -3-trifluoromethyl-iodobenzene by the procedure of Example 1, gives a 78% yield of 5-methyl-1-(3'-trifluoromethylphenyl)-2-(1H)-pyridone.

出典と根拠

ORDレコード: ord-7e768e98bfbb46bf90c0155fececd694
出典データセット: uspto-grants-1977_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04042699

反応ノート

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