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Water → 2-Isopropyl 4-methylpent-4 enoic acid, alpha-cyano-3 phenoxybenzyl ester

HRID 441842
ノート
印刷プレビュー

反応式

HRID 441842 の反応式
[CH:1]([CH:4]([CH2:8][C:9]([CH3:11])=[CH2:10])[C:5]([OH:7])=[O:6])([CH3:3])[CH3:2].[C:12]([CH:14](Br)[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([O:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:16]=1)#[N:13].C(=O)([O-])[O-].[K+].[K+].O>CC(C)=O>[CH:1]([CH:4]([CH2:8][C:9]([CH3:11])=[CH2:10])[C:5]([O:7][CH:14]([C:12]#[N:13])[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([O:21][C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:16]=1)=[O:6])([CH3:3])[CH3:2]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 12713810alpha-Cyano-3-phenoxybenzyl bromideHCID 149108594-Methyl-2-propan-2-ylpent-4-enoic acid

生成物 1

HCID 1317108682-Isopropyl 4-methylpent-4 enoic acid, alpha-cyano-3 phenoxybenzyl ester

試薬・触媒・溶媒 1

HCID 180
Acetone
溶媒

実験手順

A mixture of 2-isopropyl-4-methylpent-4-enoic acid (1.0g), alpha-cyano-3-phenoxybenzyl bromide (1.9g) and potassium carbonate (1.0g) in anhydrous acetone (40ml) was stirred at room temperature for 4 hours. Water was added to the reaction mixture and the product extracted with ether, the ethereal extracts washed with water (X2) and dried over magnesium sulphate. Evaporation of the solvent gave a crude product which was purified by chromatography on silica gel using 3% acetone in 60°-80° C. petroleum ether as eluent to give the desired ester. R.I. nD20 1.5343.

後処理

  1. extractionthe product extracted with ether
  2. washthe ethereal extracts washed with water (X2)
  3. dry with materialdried over magnesium sulphate
  4. customEvaporation of the solvent
  5. customgave a crude product which
  6. customwas purified by chromatography on silica gel using 3% acetone in 60°-80° C. petroleum ether as eluent

出典と根拠

ORDレコード
ord-36732275e3d3415d9b09f797ba180afb
出典データセット
uspto-grants-1977_08
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04042710

反応ノート

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