Piperidine → Ethyl 2-methyl-4-piperidinobutyrate

HRID 441879

反応式

HRID 441879 の反応式
Br[CH2:2][CH2:3][CH:4]([CH3:10])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[NH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>C1C=CC=CC=1>[CH3:10][CH:4]([CH2:3][CH2:2][N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)[C:5]([O:7][CH2:8][CH3:9])=[O:6]

参加物

4

反応物 2

HCID 8082PiperidineHCID 12780980Ethyl 4-bromo-2-methylbutanoate

生成物 1

HCID 20361120Ethyl 2-methyl-4-piperidinobutyrate

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

反応条件

温度
60 °C

実験手順

10.5 g. (0.05 mole) of ethyl γ-bromo-α-methylbutyrate was combined with 17.0 g. (0.20 mole) of piperidine and 100 ml. of benzene and stirred for 16 hours at room temperature and heated at 60° C. for 4 hours. The reaction mixture was cooled and the colorless solid which appeared was removed by filtration. The mother liquor was concentrated to give ethyl α-methyl-γ-piperidinobutyrate as a mobile yellow liquid which distilled (b.p. 78° C. at 0.25 mm.) as 6.7 g. (63%) of colorless liquid. The nuclear magnetic resonance and infrared spectra were consistent with the desired compound.

後処理

  1. temperatureThe reaction mixture was cooled
  2. customthe colorless solid which appeared was removed by filtration
  3. concentrationThe mother liquor was concentrated

出典と根拠

ORDレコード
ord-5285d10f4538403f9ea38ebefec88d98
出典データセット
uspto-grants-1977_08
特許番号
US04042694

関連ノート

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