2-(2-Methoxyethyl)-2-imidazoline hydrochloride → 2-(2-Methoxyethyl)-4,5-dihydro-1H-imidazole
反応式
Cl.[Na].Cl.[CH3:4][O:5][CH2:6][CH2:7][C:8]1[NH:9][CH2:10][CH2:11][N:12]=1>>[CH3:4][O:5][CH2:6][CH2:7][C:8]1[NH:12][CH2:11][CH2:10][N:9]=1参加物
3
実験手順
100 Parts of 6N sodium hydrochloride in a suitable reaction vessel are cooled to 5° C. with an ice-water bath and 22.7 parts of the 2- (2-methoxyethyl)-2 -imidazoline hydrochloride of Example 2 are added to the cold solution. An oil separates. The contents of the vessel are transferred to a separatory vessel and the aqueous phase is extracted four times with 30 parts of reagent grade tetrahydrofuran. The combined tetrahydrofuran extracts are dried over anhydrous potassium carbonate for 15 hours. The potassium carbonate is then filtered off and the tetrahydrofuran solution is distilled to yield 14.0 parts of 2-(2-methoxyethyl)-2-imidazoline.
後処理
- customThe contents of the vessel are transferred to a separatory vessel
- extractionthe aqueous phase is extracted four times with 30 parts of reagent grade tetrahydrofuran
- dry with materialThe combined tetrahydrofuran extracts are dried over anhydrous potassium carbonate for 15 hours
- filtrationThe potassium carbonate is then filtered off
- distillationthe tetrahydrofuran solution is distilled
出典と根拠
- ORDレコード
- ord-c93b7bb8442f4414953331ce66376efe
- 出典データセット
- uspto-grants-1977_08
- 特許番号
- US04044009
反応ノート
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