Ammonia → 2-(4-Nitrophenyl)ethanimidamide hydrochloride

A suspension of (4-nitrophenyl)acetonitrile (4.86 g, 30.0 mmol) in ethanol (6 mL, 99 mmol) in a 250 mL round bottom flask was slowly treated at room temperature with 4N hydrochloric acid in dioxane (38 mL, 152 mmol) and stirred for 22 hours. After carefully removing the solvent under water aspirator vacuum at 40° C. the obtained wet pale yellow product was suspended in 21 mL ethanol. Then, a 7N ammonia solution in methanol (12 mL, 84 mmol) was slowly added giving a pale gray suspension. After stirring for two hours additional 2 mL (14 mmol) 7N ammonia solution in methanol were added. After further stirring for one hour at room temperature all volatiles were removed under water aspirator vacuum at 40° C. To remove residues of ethanol and dioxane methyl t-butyl ether (30 mL) was added and once more all volatiles were removed under water aspirator vacuum at 40° C. giving an off-white solid. The crude product was used without purification in the next step.

1. customAfter carefully removing the solvent under water
2. customat 40° C.
3. customgiving a pale gray suspension
4. additionwere added
5. stirringAfter further stirring for one hour at room temperature all volatiles
6. customwere removed under water
7. customat 40° C
8. customTo remove residues of ethanol and dioxane methyl t-butyl ether (30 mL)
9. additionwas added
10. customonce more all volatiles were removed under water
11. customat 40° C.
12. customgiving an off-white solid
13. customThe crude product was used without purification in the next step

ORDレコード

ord-e6029c687e9b4c9f90cc2974bd4cd2cd

出典データセット

uspto-grants-2013_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08541419B2