化工社化工社 化学情報印刷レポート · 研究参考用
Cyanoacetamide → alpha-Cyano-beta-(2-Nitro-4,5-Dimethoxyphenyl)Acrylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyanoacetamide | HCID 7898 | — |
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 6-Nitroveratraldehyde | HCID 88505 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | alpha-Cyano-beta-(2-Nitro-4,5-Dimethoxyphenyl)Acrylamide | HCID 4145653 | — |
反応手順
Piperidine (2.1 g., 0.0237 mole) and 2-cyanoacetamide (22.0 g., 0.263 mole) are added to a slurry of 6-nitroveratraldehyde (50.0 g., 0.237 mole) in methanol (500 ml.). The mixture is heated to reflux for 2 hours, and then cooled in an ice bath and filtered. The bright yellow filter cake is washed with cold isopropanol (300 ml.) and then air dried. Yield = 60.1 g. (93%); m.p. 265°-266° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04044134 |
| 出典データセット | uspto-grants-1977_08 |
| ORD ID | ord-25c95626a215461da2793469a09d051f |
| 出典メモ | uspto-grants-1977_08 |