Diethyl Oxalate → Ethyl benzo[g]quinazolin-4(3H)-one-2-carboxylate

HRID 442220ノート

反応式

HRID 442220 の反応式
[C:1]([O:8][CH2:9][CH3:10])(=[O:7])[C:2](OCC)=O.C[O-].[Na+].[NH2:14][C:15]1[C:24]([C:25]([NH2:27])=[O:26])=[CH:23][C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=1>>[N:14]1[C:15]2[C:24](=[CH:23][C:22]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH:16]=2)[C:25](=[O:26])[NH:27][C:2]=1[C:1]([O:8][CH2:9][CH3:10])=[O:7]

参加物

4

反応物 3

HCID 7268Diethyl OxalateHCID 10942334Sodium MethoxideHCID 124714773-aMino-2-naphthaMide

生成物 1

HCID 135961510Ethyl benzo[g]quinazolin-4(3H)-one-2-carboxylate収率 79%

実験手順

Diethyl oxalate (2.35 g., 16.1 millimoles), sodium methoxide (10 mg) and 2-aminonaphthalene-3-carboxamide (1.50 g., 8.05 millimoles) are mixed together and heated at reflux for two days. The mixture is then cooled in an ice bath and the brown precipitate recovered by filtration. It is recrystallized from ethanol to give 1.76 g. (79% yield) of the desired ester. M.P. 240°-242° C.

後処理

  1. temperatureheated
  2. temperatureat reflux for two days
  3. temperatureThe mixture is then cooled in an ice bath
  4. filtrationthe brown precipitate recovered by filtration
  5. customIt is recrystallized from ethanol
  6. customto give 1.76 g

出典と根拠

ORDレコード
ord-d287f2122eb64eb7a2dc12855beccfa1
出典データセット
uspto-grants-1977_08
特許番号
US04044134

反応ノート

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