Ammonia → 4'-Fluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxamide
反応式
C[O:2][C:3](=O)[C:4]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[CH:7]=[CH:6][C:5]=1[OH:17].[NH3:19]>>[OH:17][C:5]1[CH:6]=[CH:7][C:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[CH:9][C:4]=1[C:3]([NH2:19])=[O:2]参加物
3
実験手順
A mixture of 5.3 grams of methyl-2-hydroxy-5-(4'-fluorophenyl)-benzoate and 20 ml. of liquid ammonia is reacted in a bomb at 100° C. for 4 hours. After cooling the bomb is opened and the ammonia allowed to evaporate. The residue is then recrystallized from benzene to yield 2-hydroxy-5-(4'-fluorophenyl)-benzamide (m.p. 206° - 207° C.).
後処理
- temperatureAfter cooling the bomb
- customto evaporate
- customThe residue is then recrystallized from benzene
出典と根拠
- ORDレコード
- ord-82e3831daaf14367b10a16b9af5ae4c5
- 出典データセット
- uspto-grants-1977_08
- 特許番号
- US04044049
反応ノート
読み込み中…