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Dicyclohexylcarbodiimide → palmitoyl-L-Ala-D-Glu(OSu)OBzl
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | N-Hydroxysuccinimide | HCID 80170 | — |
| 反応物 | palmitoyl-L-Ala-D-Glu(OH)OBzl | HCID 131714154 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | palmitoyl-L-Ala-D-Glu(OSu)OBzl | HCID 131714153 | 7,846.1% |
反応手順
To a solution of palmitoyl-L-Ala-D-Glu(OH)OBzl (1)(1.84 g) in a mixture of tetrahydrofuran (20 ml) and chloroform (30 ml) were added N-hydroxysuccinimide (425 mg) and dicyclohexylcarbodiimide (728 mg). The reaction mixture was kept for 18 hours at room temperature and the precipitate was filtered off and washed with chloroform. The filtrate was concentrated in vacuo and the diisopropylether was added to the residue. The product was collected and dried to afford palmitoyl-L-Ala-D-Glu(OSu)OBzl (2)(170 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04725582 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-34b5a02bca8a409287c4f086e8e5d348 |
| 出典メモ | uspto-grants-1988_02 |