Phosgene → 5-Trifluoromethylbenzothiazol-2-yl isocyanate

HRID 442378ノート

反応式

HRID 442378 の反応式
[C:1](Cl)(Cl)=[O:2].[NH2:5][C:6]1[S:7][C:8]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][C:9]=2[N:10]=1>C(OCC)(=O)C>[F:18][C:15]([F:16])([F:17])[C:12]1[CH:13]=[CH:14][C:8]2[S:7][C:6]([N:5]=[C:1]=[O:2])=[N:10][C:9]=2[CH:11]=1

参加物

4

反応物 2

HCID 6371PhosgeneHCID 70186255-(Trifluoromethyl)-1,3-benzothiazol-2-amine

生成物 1

HCID 544616495-Trifluoromethylbenzothiazol-2-yl isocyanate

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A saturated solution of phosgene in ethyl acetate (200 ml) is charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. 2-Amino-5-trifluoromethylbenzothiazole (0.1 mole) is added with stirring. After the addition is completed, the reaction mixture is heated at reflux for a period of about one hour. After this time the mixture is cooled, and the solid product formed is recovered by filtration. The solid is then dried to yield the desired product 5-trifluoromethylbenzothiazol-2-yl isocyanate dimer.

後処理

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. additionAfter the addition
  4. temperaturethe reaction mixture is heated
  5. temperatureat reflux for a period of about one hour
  6. temperatureAfter this time the mixture is cooled
  7. customthe solid product formed
  8. filtrationis recovered by filtration
  9. customThe solid is then dried

出典と根拠

ORDレコード
ord-136eb08651784e47a49c1c19eede58d9
出典データセット
uspto-grants-1977_08
特許番号
US04045446

反応ノート

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