化工社化工社 化学情報印刷レポート · 研究参考用
Formaldehyde → 4-[(1R,5S)-3-Aza-bicyclo[3.1.0]hex-3-ylmethyl]-3,5-dimethyl-1H-pyrrole-2-carbaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | 3,5-Dimethyl-1H-pyrrole-2-carbaldehyde | HCID 270465 | — |
| 反応物 | (1R,5S)-3-azabicyclo[3.1.0]hexane | HCID 13150524 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-[(1R,5S)-3-Aza-bicyclo[3.1.0]hex-3-ylmethyl]-3,5-dimethyl-1H-pyrrole-2-carbaldehyde | HCID 86662428 | — |
反応手順
To a solution of (1R,5S)-3-aza-bicyclo[3.1.0]hexane (10 mmoles) in acetic acid (10 ml) there are added 10 mmoles of 3,5-dimethyl-1H-pyrrole-2-carbaldehyde and formaldehyde (11 mmoles) 37% in water. The reaction mixture is stirred overnight at ambient temperature and then evaporated to dryness. Purification by flash chromatography on silica gel (SiO2; heptane/AcOEt) and then trituration in heptane to yield the title product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08541412B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-54cd1d7cd4c54687872c3f05d45b0da9 |
| 出典メモ | uspto-grants-2013_09 |