Triethylamine → HCID 21415057、化合物

HRID 442479ノート

反応式

HRID 442479 の反応式
Cl.Cl.[NH2:3][CH:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][CH2:12][C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:14])[CH2:6][CH2:5]1.C(N(CC)CC)C.Cl[CH2:29][C:30]([NH:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:31]>CN(C)C=O>[NH:32]([C:30]([CH2:29][NH:3][CH:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][CH2:12][C:13]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[O:14])[CH2:6][CH2:5]1)=[O:31])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1

参加物

5

反応物 3

HCID 8471Triethylamine2 回HCID 11485ChloroacetanilideHCID 227548374-Amino-1-(4-phenyl-4-oxobutyl)piperidine dihydrochloride

生成物 1

HCID 21415057HCID 21415057、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

4-Amino -1-(4-phenyl-4-oxobutyl) piperidine dihydrochloride (1.75g) was suspended in dimethylformamide (15 ml) containing triethylamine (3 ml) and chloroacetanilide (0.85G) added. The mixture was stirred for 48 hours and the precipitate of Et3N.HC1 filtered off. The filtrate was poured into water and the solid product filtered off and recrystallised from EtOH/H2O to give the title compound (1.35g). This was converted to the hydrochloride (1.35g) by treatment with EtOH-HC1 and Et2O, m.p. 255.1°.

後処理

  1. additionadded
  2. filtrationHC1 filtered off
  3. additionThe filtrate was poured into water
  4. filtrationthe solid product filtered off
  5. customrecrystallised from EtOH/H2O

出典と根拠

ORDレコード
ord-10d16e777b1242f892b6b2ef833ada11
出典データセット
uspto-grants-1977_08
特許番号
US04045566

反応ノート

読み込み中…