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Phenethyl Isothiocyanate → 1-(4-Chloro-2-(alpha-hydroxybenzyl)benzyl)-3-phenethylthiourea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenethyl Isothiocyanate | HCID 16741 | — |
| 反応物 | Benzenemethanol,2-(aminomethyl)-5-chloro-a-phenyl- | HCID 12241006 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 1-(4-Chloro-2-(alpha-hydroxybenzyl)benzyl)-3-phenethylthiourea | HCID 21415460 | — |
反応手順
2-aminomethyl-5-chlorobenzhydrol (10 g; 0.04 mole) in 100 ml methanol and 2 ml triethylamine was treated dropwise with a solution of phenethyl isothiocyanate (8.6 g; 0.053 mole) in 25 ml of methanol. After 16 hours at room temperature the reaction mixture was evaporated and the residue was extracted with petroleum ether. The residual oil was recrystallized from diisopropyl ether to yield 1-(4-chloro-2-(α-hydroxybenzyl)benzyl)-3-phenethylthiourea as a white powder (M.Pt. 97° -- 101° ).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04045572 |
| 出典データセット | uspto-grants-1977_08 |
| ORD ID | ord-93903d4497c1482bb535b4bb2fd9bcc5 |
| 出典メモ | uspto-grants-1977_08 |