Imidazole → 2,4-Dichloro-beta-(1-imidazolyl)propiophenone

HRID 442508ノート

反応式

HRID 442508 の反応式
C(C(C1C=[CH:9][C:8]([Cl:11])=[CH:7]C=1Cl)=O)=C.[Cl:13][C:14]1[CH:19]=C(Cl)C=CC=1C(C=C)O.Br[C:26]1[C:27](=O)[C:28](Br)=[CH:29][C:30](Br)(Br)[CH:31]=1.[NH:36]1C=C[N:38]=[CH:37]1.CC[O:43]CC>>[Cl:11][CH:8]([CH2:7][N:36]1[CH:19]=[C:14]([Cl:13])[N:38]=[CH:37]1)[C:9]([C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)=[O:43]

参加物

6

反応物 5

HCID 795ImidazoleHCID 3283Diethyl EtherHCID 884332,4,4,6-Tetrabromocyclohexa-2,5-dienoneHCID 202826161-(2,4-Dichlorophenyl)prop-2-en-1-olHCID 202826771-(2,4-Dichlorophenyl)prop-2-en-1-one

生成物 1

HCID 536940332,4-Dichloro-beta-(1-imidazolyl)propiophenone

実験手順

7.0 g. of 2,4-dichlorophenyl vinyl ketone (prepared by Jones oxidation of 2,4-dichlorophenyl vinyl carbinol using the general method described in J. Chem. Soc. (C), 1966, p. 1972) in 350 ml. of anhydrous ether was treated with 3.5 g. of imidazole, the solution stirred overnight and then washed with water (3 × 30 ml.). The solution is dried (MgSO4) and evaporated to give 2,4-dichloro-β-(1-imidazolyl)propiophenone as an amber gum (8.65 g.). The hydrochloride salt may be precipitated from ether and recrystallized from methanol/acetone as colorless rods, m.p. 105.5°-110° C.

後処理

  1. washwashed with water (3 × 30 ml.)
  2. dry with materialThe solution is dried (MgSO4)
  3. customevaporated

出典と根拠

ORDレコード
ord-2b1a10289aac4060948347073ffdb68f
出典データセット
uspto-grants-1977_08
特許番号
US04045568

反応ノート

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