Dimethylformamide → Octyl 4'-hydroxy-4-biphenylcarboxylate

HRID 442597

反応式

HRID 442597 の反応式
FC(F)(F)[CH:3]([OH:10])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].CN(C)[CH:15]=[O:16].[CH2:18](N(CC)CC)[CH3:19].[CH:25]1[C:34]2[C:29](=[CH:30][C:31]([C:35](Cl)=[O:36])=[CH:32][CH:33]=2)C=C[C:26]=1[C:38](Cl)=O.[CH2:41](Cl)Cl>>[CH2:3]([O:10][C:35]([C:31]1[CH:32]=[CH:33][C:34]([C:25]2[CH:26]=[CH:38][C:15]([OH:16])=[CH:19][CH:18]=2)=[CH:29][CH:30]=1)=[O:36])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:41]

参加物

6

反応物 5

HCID 6228DimethylformamideHCID 6344Dichloromethane2 回HCID 8471TriethylamineHCID 978042-Octanol, 1,1,1-trifluoro-HCID 34855962,6-Naphthalenedicarbonyl dichloride

生成物 1

HCID 14692993Octyl 4'-hydroxy-4-biphenylcarboxylate

実験手順

Optically active 1,1,1-trifluoro-2-octanol (0.3 g), dimethylformamide (0.2 g) and triethylamine (0.18 g) were dissolved in methylene chloride (20 ml). To this solution was added in small portions a solution of 2,6-naphthalenedicarboxylic acid dichloride (0.8 g) obtained in the step 2) of Example 7 in methylene chloride (50 ml) under ice-cooling, and the mixture was stirred for about 20 hours. Next, 4-n-octyloxycarbonyl-4'-hydroxybiphenyl (0.55 g) obtained in the step 1) was dissolved in methylene chloride (30 ml) and added in small portions to the reaction mixture. The resulting mixture was stirred for about 20 hours.

後処理

  1. temperaturecooling

出典と根拠

ORDレコード
ord-401bdc46047c4f3aa69c17a8d3cd0a1a
出典データセット
uspto-grants-1999_04
特許番号
US05891359

関連ノート

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