化工社化工社 化学情報印刷レポート · 研究参考用
1,2,3,6-Tetrahydropyridine → 1-(1,3-Benzoxazol-5-ylcarbonyl)-1,2,3,6-tetrahydropyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,2,3,6-Tetrahydropyridine | HCID 12750 | — |
| 反応物 | Methanol, 1,1-diethoxy-, 1-acetate | HCID 84166 | — |
| 反応物 | 4-Amino-3-hydroxybenzoic acid | HCID 137566 | — |
| 反応物 | 1-(1,3-Benzoxazol-6-ylcarbonyl)-1,2,3,6-tetrahydropyridine | HCID 11535940 | — |
| 反応物 | 1,3-Benzoxazole-5-carboxylic acid | HCID 19006767 | — |
| 生成物 | 1-(1,3-Benzoxazol-5-ylcarbonyl)-1,2,3,6-tetrahydropyridine | HCID 11651526 | — |
反応手順
4-Amino-3-hydroxybenzoic acid is converted into 1,3-benzoxazol-5-carboxylic acid by treating with diethoxymethyl acetate as described for the preparation of Invention Compound IX. EMIS m/z=163 (parent), 146 (base), 118, 90, and 63. Coupling of the acid with 1,2,3,6-tetrahydropyridine is performed in the same manner as described for the preparation of isomeric Invention Compound IX. 1H NMR δ 2.1-2.4 (br, 4), 3.4-4.3 (br m, 4), 5.5-5.95 (br m, 2), 7.45 (dd, 1, J=8.17, 1.41 Hz), 7.70 (d, 1, J=0.96 Hz), 7.83 (d, 1, J=8.16 Hz), and 8.18 ppm (s, 1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05891876 |
| 出典データセット | uspto-grants-1999_04 |
| ORD ID | ord-0a3479216f8c4baaa93ce061d956fa91 |
| 出典メモ | uspto-grants-1999_04 |