Piperidine → 1-(Quinoxalin-6-ylcarbonyl)piperidine
反応式
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([OH:13])=O)=[CH:8][CH:9]=2)[N:4]=[CH:3][CH:2]=1.[NH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1.C(C1NC=CN=1)(C1NC=CN=1)=O>>[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([N:14]3[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]3)=[O:13])=[CH:8][CH:9]=2)[N:4]=[CH:3][CH:2]=1参加物
4
実験手順
The coupling of 6-quinoxalinecarboxylic acid to piperidine is accomplished in a manner similar to that used for the preparation of Invention Compound XIII, or by any other method known in the art for activation of aromatic carboxylic acids, such as, for example, activation by carbonyl diimidazole. 1H NMR δ 1.56 and 1.73 (br, 6), 3.40 (br s, 2), 3.79 (br s, 2), 7.82 (dd, 1, J=8.8, 1.9Hz), 8.13 (d, 1, J=1.6 Hz), 8.17 (d, 1, 8.6 Hz), and 8.9 ppm (m, 2).
出典と根拠
- ORDレコード
- ord-10e3d0b07b8b4fd699e6754aa8a709f8