化工社化工社 化学情報印刷レポート · 研究参考用
Monoethyl malonate → Ethyl 3-(4-bromo-2-methylphenyl)-3-oxopropanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Monoethyl malonate | HCID 70615 | — |
| 反応物 | Lithium, mol. (Li2) | HCID 139759 | — |
| 反応物 | 4-Bromo-2-methylbenzoyl chloride | HCID 12846483 | — |
| 生成物 | Ethyl 3-(4-bromo-2-methylphenyl)-3-oxopropanoate | HCID 53404613 | — |
反応手順
2-Methyl-4-bromobenzoyl chloride (29.1 g, 0.13 mol) was treated with the dilithium salt of ethyl hydrogen malonate (28.0 g, 0.21 mol) and the product was isolated by the procedure described in Example 1 (ii). The crude product was purified on flash silica, eluting with dichloromethane-hexane (1:1 then 3:2) to give ethyl 2-methyl-4-bromobenzoylacetate as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05891899 |
| 出典データセット | uspto-grants-1999_04 |
| ORD ID | ord-ddc09ecaf6e64ae8b211449d5c77514a |
| 出典メモ | uspto-grants-1999_04 |