p-Chlorophenacyl bromide → 1-(4-Chlorophenyl)-2-hydroxyethan-1-one
反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)=[O:4].C([O-])=[O:13].[K+]>CO>[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][OH:13])=[CH:6][CH:7]=1参加物
4
実験手順
A mixture of 2-bromo-1-(4-chloro-phenyl)-ethanone (100 mmoles) and potassium formate (130 mmoles) in MeOH (100 ml) is stirred at reflux for 3 hours. The reaction mixture is poured onto crushed ice. The solid formed is filtered off, washed with cold MeOH and then dried in vacuo to yield the title product, which is used directly in the next Step.
後処理
- temperatureat reflux for 3 hours
- additionThe reaction mixture is poured
- customonto crushed ice
- customThe solid formed
- filtrationis filtered off
- washwashed with cold MeOH
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-ab2f5eac5e324d2490f3ca2c3523ed47
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08541412B2
反応ノート
読み込み中…