tert-Butyl bromoacetate → tert-butyl (1S,2S)-(6-fluoro-2-hydroxy-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl)acetate
反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C@H:8]([CH:12]([CH3:14])[CH3:13])[C@:7]([CH2:16][CH2:17][O:18]S(C1C=CC(C)=CC=1)(=O)=O)([OH:15])[CH2:6][CH2:5]2.FC1C=C2C(=CC=1)[C@H](C(C)C)C(=O)CC2.BrCC([O:48][C:49]([CH3:52])([CH3:51])[CH3:50])=O.[Mg]>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C@H:8]([CH:12]([CH3:14])[CH3:13])[C@:7]([CH2:16][C:17]([O:48][C:49]([CH3:52])([CH3:51])[CH3:50])=[O:18])([OH:15])[CH2:6][CH2:5]2参加物
5
