Hydrochloric Acid → 4-(3-Methylphenyl)-4-hydroxypiperidine hydrochloride

HRID 443216ノート

反応式

HRID 443216 の反応式
C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[CH:16]=2)([OH:14])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>CCOC(C)=O>[ClH:22].[CH3:21][C:17]1[CH:16]=[C:15]([C:11]2([OH:14])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:20]=[CH:19][CH:18]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 21193300N-t-Butoxycarbonyl-4-(3-methylphenyl)-4-hydroxy piperidine

生成物 1

HCID 211931674-(3-Methylphenyl)-4-hydroxypiperidine hydrochloride

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of N-t-butoxycarbonyl-4-(3-methylphenyl)-4-hydroxy piperidine (0.546 mg, 1.87 mmol) in EtOAc (30 ml) at 0° C. was bubbled gasseous HCl until saturated. After 10 min the solvent was evaporated in vacuo to afford the title compound of sufficient purity to be used in the next step.

後処理

  1. customAfter 10 min the solvent was evaporated in vacuo

出典と根拠

ORDレコード
ord-8446683b209e4700a6482f9df30aa441
出典データセット
uspto-grants-1999_04
特許番号
US05891889

反応ノート

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