Hydrochloric Acid → HCID 21193404、化合物

HRID 443220ノート

反応式

HRID 443220 の反応式
[CH3:1][O:2][C:3](=[O:25])[C:4]1([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH3:24])[CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][CH2:5]1.[ClH:26]>CCOC(C)=O>[ClH:26].[CH3:1][O:2][C:3](=[O:25])[C:4]1([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH3:24])[CH2:5][CH2:6][NH:7][CH2:8][CH2:9]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 537754431-(1,1-Dimethylethyl) 4-methyl 4-[(2-methylphenyl)methyl]-1,4-piperidinedicarboxylate

生成物 1

HCID 21193404HCID 21193404、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
0 °C

実験手順

To a solution of N-t-butoxycarbonyl-4-(2-methylbenzyl)-isonipecotic acid methyl ester (7.13 g, 20.5 mmol) in EtOAc (100 ml) at 0° C. was bubbled HCl gas until saturated. The reaction was stirred for 10 min at 0° C. and the solvent evaporated in vacuo to afford the product as a white solid.

後処理

  1. customthe solvent evaporated in vacuo

出典と根拠

ORDレコード
ord-4a1e16fb391b485a8da131711b01c9f0
出典データセット
uspto-grants-1999_04
特許番号
US05891889

反応ノート

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